RAF Typhoon FGR4s have operated alongside French aircraft in a combined operation against an underground arms cache in Syria employed by the IS group, per a report from the British defence ministry.
The site, located using intelligence, was assessed as storing arms and explosives, the announcement noted, and was situated in mountains just to the north of the ancient city of Palmyra in the heart of Syria.
"Our aircraft used Paveway IV guided bombs to target a series of entry passages down to the depot... initial indications indicate the target was engaged successfully," the ministry announced.
There was no indication of any harm to civilians in the attack on Saturday evening and each participating jet returned safely, the defence officials confirmed.
The Typhoon FGR4s were backed up by a Voyager aerial refuelling aircraft.
The Islamic State group - alternatively referred to as ISIS - established extremist governance over significant areas in Iraq and Syria before its territorial defeat in 2019.
"This operation underscores our UK leadership, and determination to stand shoulder to shoulder with allied nations, to eradicate any revival of Daesh and their violent and radical beliefs in the Middle East," the British Defence Secretary the Defence Secretary said.
UK warplanes have performed surveillance missions over Syrian airspace to "deter any efforts to regroup" of IS subsequent to its military defeat at the battle of Baghuz in 2019, the MoD reported.
"I extend gratitude to the personnel of British forces involved in this operation for their skill and their bravery," Healey added. "Including them were thousands of British personnel stationed over the festive period. This operation, to remove dangerous terrorists who endanger our safety, demonstrates how our armed forces are ready to step up, continuously, ensuring Britain's security domestically and strong abroad."
Last December, the United States armed forces conducted what it described as a "large-scale strike" on IS targets in the country, following an assault claimed the lives of two US troops and a civilian interpreter in the Palmyra area.
The UN says Islamic State still boasts roughly 5-7 thousand militants in both countries.
